This paper explores the basic processes around an MCR as well as its advantages and disadvantages and provides a couple of recommendations on how an “ideal” MCR should be conducted. Trade-offs researchers should be aware of in designing an MCR will be explored.

The previously validated (indications: atrial fibrillation, human immunodeficiency virus, chronic inflammatory lung disease) Adherence Barriers Questionnaire (ABQ) was revised according to specifications of IVT, within the framework of an expert panel. A cross-sectional patient survey was conducted in combination with a retrospective medical chart review in order to validate the developed new instrument (ABQ-IVT).

As there is a general lack of data around T2DM patients newly initiating an insulin therapy, it was the main objective of this study to collect these data. The main strength of this analysis is the use of a large claims dataset unaffected by any selection bias and an additional collection of MCR data for reasons of a validity check of claims data analysis results, as the claims data specifically addressed two German states.